Proteasome inhibition suppresses Schwann cell dedifferentiation in vitro and in vivo.

@article{Lee2009ProteasomeIS,
  title={Proteasome inhibition suppresses Schwann cell dedifferentiation in vitro and in vivo.},
  author={Hyun Kyoung Lee and Yoon Kyung Shin and Junyang Jung and Su-Yeong Seo and Sun-Yong Baek and Hwan Tae Park},
  journal={Glia},
  year={2009},
  volume={57 16},
  pages={1825-34}
}
The ubiquitin-proteasome system (UPS), lysosomes, and autophagy are essential protein degradation systems for the regulation of a variety of cellular physiological events including the cellular response to injury. It has recently been reported that the UPS and autophagy mediate the axonal degeneration caused by traumatic insults and the retrieval of nerve growth factors. In the peripheral nerves, axonal degeneration after injury is accompanied by myelin degradation, which is tightly related to… CONTINUE READING

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