Proteasome inhibition induces neurite outgrowth through posttranslational modification of TrkA receptor.


The ubiquitin-proteasome pathway regulates many biological processes, including protein degradation, receptor endocytosis, protein sorting, subnuclear trafficking and neuronal differentiation. While proteasome inhibition is known to induce neurite outgrowth, the signaling mechanisms that mediate these effects have not been defined. In this study, we… (More)
DOI: 10.1016/j.biocel.2008.04.022