Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins.

@article{Ding2001ProteasomeII,
  title={Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins.},
  author={Qunxing Ding and Jeffrey N. Keller},
  journal={Journal of neurochemistry},
  year={2001},
  volume={77 4},
  pages={1010-7}
}
Recent studies have demonstrated that inhibition of the proteasome, an enzyme responsible for the majority of intracellular proteolysis, may contribute to the toxicity associated with oxidative stress. In the present study we demonstrate that exposure to oxidative injury (paraquat, H(2)O(2), FeSO(4)) induces a rapid increase in reactive oxygen species (ROS), loss of mitochondrial membrane potential, inhibition of proteasome activity, and induction of cell death in neural SH-SY5Y cells… CONTINUE READING

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