Proteasome inhibition in myelodysplastic syndromes and acute myelogenous leukemia cell lines.

@article{Liesveld2011ProteasomeII,
  title={Proteasome inhibition in myelodysplastic syndromes and acute myelogenous leukemia cell lines.},
  author={Jane L Liesveld and Karen E. Rosell and Jeremy Bechelli and Chaohui Lu and Patti Messina and Deborah A. Mulford and Jainulabdeen J Ifthikharuddin and Craig T. Jordan and Gordon L Phillips},
  journal={Cancer investigation},
  year={2011},
  volume={29 7},
  pages={439-50}
}
In this work, effects of bortezomib on apoptosis, clonal progenitor growth, cytokine production, and NF-κB expression in patients with MDS with cytopenias requiring transfusion support are examined. Bortezomib increased apoptosis in marrow mononuclear cells but had no effects on CFU-GM, BFU-E, or CFU-L content. No consistent effects on NF-κB activation in vivo were noted. To further define the role of bortezomib in AML and MDS, we examined it in combination with several targeted agents and… CONTINUE READING