Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

  title={Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness},
  author={Shilpi Khare and Advait S. Nagle and Agnes Biggart and Yin Hung Lai and Fang Qing Liang and Lauren C. Davis and Samantha Barnes and Casey Jacob Nelson Mathison and Elmarie Myburgh and M Gao and J Robert Gillespie and Xianzhong Liu and Jocelyn L. Tan and Monique J. Stinson and Ianne C. Rivera and Jaime Ballard and Vince S. C. Yeh and T. K. Groessl and Glenn C Federe and Hazel X. Y. Koh and John D. Venable and Badry D. Bursulaya and Michael Shapiro and Pranab K. Mishra and Glen Spraggon and Ansgar Brock and Jeremy C Mottram and Frederick S Buckner and Srinivasa Patibandla Rao and Ben G. Wen and John R. Walker and Tove Tuntland and Valentina Molteni and Richard J. Glynne and Frantisek Supek},
Chagas disease, leishmaniasis and sleeping sickness affect 20 million people worldwide and lead to more than 50,000 deaths annually. The diseases are caused by infection with the kinetoplastid parasites Trypanosoma cruzi, Leishmania spp. and Trypanosoma brucei spp., respectively. These parasites have similar biology and genomic sequence, suggesting that all three diseases could be cured with drugs that modulate the activity of a conserved parasite target. However, no such molecular targets or… CONTINUE READING
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Comparative genomics of trypanosomatid parasitic protozoa

  • El-Sayed, M N.
  • Science 309,
  • 2005
Highly Influential
8 Excerpts

Structure- and function-based design of Plasmodium-selective proteasome inhibitors

  • H Li
  • Nature 530,
  • 2016

Randomized trial of benznidazole for chronic Chagas' cardiomyopathy

  • Morillo, A C.
  • The New 235 England Journal of Medicine 373,
  • 2015

toward a new era

  • Chatelain, E. Chagas disease drug discovery
  • Journal of Biomolecular Screening 203 20, 22-35…
  • 2015

Randomized trial of posaconazole and benznidazole for chronic Chagas' disease

  • I Molina
  • New England Journal of Medicine 370,
  • 2014

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