Proteasome inhibition enhances the induction and impairs the maintenance of late-phase long-term potentiation.

Abstract

Protein degradation by the ubiquitin-proteasome pathway plays important roles in synaptic plasticity, but the molecular mechanisms by which proteolysis regulates synaptic strength are not well understood. We investigated the role of the proteasome in hippocampal late-phase long-term potentiation (L-LTP), a model for enduring synaptic plasticity. We show… (More)
DOI: 10.1101/lm.984508

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