Proteasome inhibition enhances the induction and impairs the maintenance of late-phase long-term potentiation.

@article{Dong2008ProteasomeIE,
  title={Proteasome inhibition enhances the induction and impairs the maintenance of late-phase long-term potentiation.},
  author={Chenghai Dong and Sudarshan C Upadhya and Lan Ding and Thuy K. Smith and Ashok N. Hegde},
  journal={Learning & memory},
  year={2008},
  volume={15 5},
  pages={335-47}
}
Protein degradation by the ubiquitin-proteasome pathway plays important roles in synaptic plasticity, but the molecular mechanisms by which proteolysis regulates synaptic strength are not well understood. We investigated the role of the proteasome in hippocampal late-phase long-term potentiation (L-LTP), a model for enduring synaptic plasticity. We show here that inhibition of the proteasome enhances the induction of L-LTP, but inhibits its maintenance. Proteasome inhibitor-mediated enhancement… CONTINUE READING

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