Proteasome inhibition ablates activation of NF-kappa B in myocardial reperfusion and reduces reperfusion injury.

@article{Pye2003ProteasomeIA,
  title={Proteasome inhibition ablates activation of NF-kappa B in myocardial reperfusion and reduces reperfusion injury.},
  author={J. Philip Pye and Farhad Ardeshirpour and Arlene S McCain and Dwight A. Bellinger and Elizabeth P. Merricks and Julian Robert James Adams and Peter J. Elliott and Christine Pien and Thomas H. Fischer and Albert S. Baldwin and Timothy C. Nichols},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={284 3},
  pages={
          H919-26
        }
}
Both acute coronary occlusion and reperfusion of an infarct-related artery lead to significant myocardial cell death. Recent evidence has been presented that activation of the transcription factor nuclear factor-kappaB (NF-kappaB) plays a critical role in reperfusion injury. NF-kappaB is usually bound to its inhibitor, IkappaB, and classic activation of NF-kappaB occurs when the 20S proteasome degrades IkappaB that has been phosphorylated and ubiquitinated. In this study, activation of NF… 
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Regulation of the proteasome by ATP: implications for ischemic myocardial injury and donor heart preservation.
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  • Biology
    American journal of physiology. Heart and circulatory physiology
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TLDR
The paradoxical findings that proteasome inhibitors showed beneficial effects when administered during reperfusion in some studies could be explained by their anti-inflammatory and immune suppressive actions, leading to reduction of leukocyte-mediated myocardial reperfusions injury.
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