Proteasome-independent activation of nuclear factor kappaB in cytoplasmic extracts from human endothelial cells by Rickettsia rickettsii.

@article{Sahni1998ProteasomeindependentAO,
  title={Proteasome-independent activation of nuclear factor kappaB in cytoplasmic extracts from human endothelial cells by Rickettsia rickettsii.},
  author={Sanjeev K Sahni and D J Van Antwerp and Marina E. Eremeeva and David J. Silverman and Victor J. Marder and Lee Ann Sporn},
  journal={Infection and immunity},
  year={1998},
  volume={66 5},
  pages={1827-33}
}
Interaction of many infectious agents with eukaryotic host cells is known to cause activation of the ubiquitous transcription factor nuclear factor kappaB (NF-kappaB) (U. Siebenlist, G. Franzoso, and K. Brown, Annu. Rev. Cell Biol. 10:405-455, 1994). Recently, we reported a biphasic pattern of NF-kappaB activation in cultured human umbilical vein endothelial cells consequent to infection with Rickettsia rickettsii, an obligate intracellular gram-negative bacterium and the etiologic agent of… CONTINUE READING

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