Proteasome dysfunction in aged human alpha-synuclein transgenic mice.

  title={Proteasome dysfunction in aged human alpha-synuclein transgenic mice.},
  author={Li Chen and Mona J. Thiruchelvam and Kiran Madura and Eric K. Richfield},
  journal={Neurobiology of disease},
  volume={23 1},
A deficit in proteasome function in Parkinson's disease has been speculated. We characterized the ubiquitin-proteasome system in three regions of brain from transgenic and nontransgenic littermates. Mice expressing a doubly mutated form of human alpha-synuclein had significant impairments whereas mice expressing the wild-type gene had lesser changes compared to nontransgenic littermates. Significant abnormalities in line hm2 alpha-SYN-39 included declines in 20S-mediated proteolytic activity… CONTINUE READING
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