Proteasome blockers inhibit TNF-alpha release by lipopolysaccharide stimulated macrophages and microglia: implications for HIV-1 dementia.

@article{Fine1999ProteasomeBI,
  title={Proteasome blockers inhibit TNF-alpha release by lipopolysaccharide stimulated macrophages and microglia: implications for HIV-1 dementia.},
  author={Shari Fine and Sanjay B. Maggirwar and Peter R. Elliott and Leon G. Epstein and Harris A. Gelbard and Stephen Dewhurst},
  journal={Journal of neuroimmunology},
  year={1999},
  volume={95 1-2},
  pages={55-64}
}
HIV-1 infection of the central nervous system can cause severe neurologic disease although only microglial cells and brain macrophages are susceptible to productive viral infection. Substances secreted by infected cells are thought to cause disease indirectly. Tumor necrosis factor alpha (TNF-alpha) is one candidate neurotoxin and is upregulated during HIV-1 infection of the brain, likely via activation of the transcription factor NF-kappaB. We used the proteasome inhibitors, MG132 and ALLN (N… CONTINUE READING
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