Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

  title={Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin},
  author={Atsushi Tanaka and Megan M. Cleland and Shan Xu and Derek P. Narendra and Der-Fen Suen and Mariusz Karbowski and Richard J Youle},
  booktitle={The Journal of cell biology},
Damage to mitochondria can lead to the depolarization of the inner mitochondrial membrane, thereby sensitizing impaired mitochondria for selective elimination by autophagy. However, fusion of uncoupled mitochondria with polarized mitochondria can compensate for damage, reverse membrane depolarization, and obviate mitophagy. Parkin, an E3 ubiquitin ligase that is mutated in monogenic forms of Parkinson's disease, was recently found to induce selective autophagy of damaged mitochondria. Here we… CONTINUE READING
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PINK 1 / Parkinmediated mitophagy is dependent on VDAC 1 and p 62 / SQSTM 1

  • J. C. Greene, L. A. Andrews
  • Nat . Cell Biol .
  • 2010

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