Proteasome activities decrease during dexamethasone-induced apoptosis of thymocytes.

  title={Proteasome activities decrease during dexamethasone-induced apoptosis of thymocytes.},
  author={J Beyette and Grant G. F. Mason and Rachael Z Murray and Gerald M. Cohen and A. Jennifer Rivett},
  journal={The Biochemical journal},
  volume={332 ( Pt 2)},
The induction of apoptosis in thymocytes by the glucocorticoid dexamethasone was used as a model system to investigate whether there are changes in 20 S and 26 S proteasome activities during apoptosis. We observed that thymocytes contain high concentrations of proteasomes and that following treatment with dexamethasone, cell extracts showed a decrease in proteasome chymotrypsin-like activity which correlated with the degree of apoptosis observed. The decrease in chymotrypsin-like activity of 20… CONTINUE READING


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Apoptosis in Normal Development and Cancer

  • S. W. Lowe
  • 1996

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