Proteasome Structure and Assembly.

  title={Proteasome Structure and Assembly.},
  author={Lauren Budenholzer and Chin Leng Cheng and Yanjie Li and Mark Hochstrasser},
  journal={Journal of molecular biology},
  volume={429 22},
The eukaryotic 26S proteasome is a large multisubunit complex that degrades the majority of proteins in the cell under normal conditions. The 26S proteasome can be divided into two subcomplexes: the 19S regulatory particle and the 20S core particle. Most substrates are first covalently modified by ubiquitin, which then directs them to the proteasome. The function of the regulatory particle is to recognize, unfold, deubiquitylate, and translocate substrates into the core particle, which contains… CONTINUE READING

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