Proteasome Inhibition Suppresses Dengue Virus Egress in Antibody Dependent Infection

  title={Proteasome Inhibition Suppresses Dengue Virus Egress in Antibody Dependent Infection},
  author={Milly Ming Ju Choy and Summer Li-Xin Zhang and Vivian Vasconcelos Costa and Hwee Cheng Tan and Sophie K. Horrevorts and Eng Eong Ooi and Rhoel R Dinglasan},
  booktitle={PLoS neglected tropical diseases},
The mosquito-borne dengue virus (DENV) is a cause of significant global health burden, with an estimated 390 million infections occurring annually. However, no licensed vaccine or specific antiviral treatment for dengue is available. DENV interacts with host cell factors to complete its life cycle although this virus-host interplay remains to be fully elucidated. Many studies have identified the ubiquitin proteasome pathway (UPP) to be important for successful DENV production, but how the UPP… CONTINUE READING
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