Proteasome Inhibition Is Partially Effective in Attenuating Pre-Existing Immunity against Recombinant Adeno-Associated Viral Vectors

@inproceedings{Karman2012ProteasomeII,
  title={Proteasome Inhibition Is Partially Effective in Attenuating Pre-Existing Immunity against Recombinant Adeno-Associated Viral Vectors},
  author={Jozsef Karman and Nathan K. Gumlaw and Jinhua Zhang and Ji-Lei Jiang and Seng H. Cheng and Yunxiang Zhu},
  booktitle={PloS one},
  year={2012}
}
Pre-existing immunity against adeno-associated virus (AAV) remains a major challenge facing the clinical use of systemic administration of recombinant AAV vectors for the treatment of genetic and acquired diseases using gene therapy. In this study, we evaluated the potential of bortezomib (marketed under trade name Velcade) to abrogate a pre-existing immunity to AAV in mice, thereby allowing subsequent transduction by a recombinant AAV vector of the same serotype. We demonstrate that bortezomib… CONTINUE READING