Proteasome Inhibition Drives HDAC6-Dependent Recruitment of Tau to Aggresomes

  title={Proteasome Inhibition Drives HDAC6-Dependent Recruitment of Tau to Aggresomes},
  author={Chris R. Guthrie and Brian C Kraemer},
  journal={Journal of Molecular Neuroscience},
Lesions containing aggregated and hyperphosphorylated tau protein are characteristic of neurodegenerative tauopathies. We have developed a cellular model of pathological tau deposition and clearance by overexpressing wild type human tau in HEK293 cells. When proteasome activity is inhibited, HEK293/tau cells accumulate tau protein in structures that bear many of the hallmarks of aggresomes. These include recruitment of tau into large spherical inclusions, accumulation of the retrograde motor… CONTINUE READING


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