Proteasomal degradation of human CYP1B1: effect of the Asn453Ser polymorphism on the post-translational regulation of CYP1B1 expression.

@article{Bandiera2005ProteasomalDO,
  title={Proteasomal degradation of human CYP1B1: effect of the Asn453Ser polymorphism on the post-translational regulation of CYP1B1 expression.},
  author={Silvio Bandiera and Simone Weidlich and Volker Harth and Peter Br{\"o}de and Yun Woong Ko and Thomas H Friedberg},
  journal={Molecular pharmacology},
  year={2005},
  volume={67 2},
  pages={435-43}
}
Allelic variations in CYP1B1 are reported to modulate the incidence of several types of cancer. To provide a mechanistic basis for this association, we investigated the impact of nonsilent allelic changes on the intracellular levels and post-translational regulation of CYP1B1 protein. When transiently expressed in COS-1 cells, either in the presence or absence of recombinant cytochrome P450 reductase, the cellular level of the CYP1B1.4 allelic variant (containing a Ser at the amino acid… CONTINUE READING