Proteasomal degradation of Kir6.2 channel protein and its inhibition by a Na+ channel blocker aprindine.

Abstract

ATP-sensitive K+ channels (K(ATP):SUR2A+Kir6.2) play a pivotal role in cardiac protection against ischemia and reperfusion injury. When expressed in COS cells, Kir6.2 was short-lived with a half-life time of 1.9 h. The half-life time of Kir6.2 was prolonged by proteasome inhibitors MG132, ALLN, proteasome inhibitor 1, and lactacystine, but not at all by a… (More)

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@article{Tanaka2005ProteasomalDO, title={Proteasomal degradation of Kir6.2 channel protein and its inhibition by a Na+ channel blocker aprindine.}, author={Hiroaki Tanaka and Junichiro Miake and Tomomi Notsu and Kazuhiko Sonyama and Norihito Sasaki and Kazuhiko Iitsuka and Masaru Kato and Shin-ichi Taniguchi and Osamu Igawa and Akio Yoshida and Chiaki Shigemasa and Yoshiko Hoshikawa and Yasutaka Kurata and Akihiko Kuniyasu and Hitoshi Nakayama and Nobuo Inagaki and Eiji Nanba and Goshi Shiota and Takayuki Morisaki and Haruaki Ninomiya and Masafumi Kitakaze and Ichiro Hisatome}, journal={Biochemical and biophysical research communications}, year={2005}, volume={331 4}, pages={1001-6} }