Proteases present in some pancreatic cyst fluids may affect mucin immunoassay by degrading antibodies and antigens.

@article{ForgueLafitte2010ProteasesPI,
  title={Proteases present in some pancreatic cyst fluids may affect mucin immunoassay by degrading antibodies and antigens.},
  author={Marie-Elisabeth Forgue-Lafitte and Ritu Arambam and Jacques Bara},
  journal={Pancreas},
  year={2010},
  volume={39 7},
  pages={
          1070-6
        }
}
OBJECTIVES Biomarker detection in pancreatic cyst fluids is of importance to improve the diagnosis of mucinous cystadenoma, a precancerous lesion. However, assay protocols are generally established for serum testing. METHODS Immunoradiometric assay of gastric M1/MUC5AC mucin was performed on pancreatic cyst fluids with well-characterized monoclonal antibodies. RESULTS Among 1466 pancreatic cyst fluids tested, about 10% to 15% of samples presented abnormal behaviors: (i) radioactivity… CONTINUE READING
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