Proteases involved during oxidative stress-induced poly(ADP-ribose) polymerase-mediated cell death in Dictyostelium discoideum.

@article{Rajawat2014ProteasesID,
  title={Proteases involved during oxidative stress-induced poly(ADP-ribose) polymerase-mediated cell death in Dictyostelium discoideum.},
  author={Jyotika Rajawat and T. Frase Alex and Hina A Mir and Ashlesha A Kadam and Rasheedunnisa Begum},
  journal={Microbiology},
  year={2014},
  volume={160 Pt 6},
  pages={
          1101-11
        }
}
Apoptosis involves a cascade of caspase activation leading to the ordered dismantling of critical cell components. However, little is known about the dismantling process in non-apoptotic cell death where caspases are not involved. Dictyostelium discoideum is a good model system to study caspase-independent cell death where experimental accessibility of non-apoptotic cell death is easier and molecular redundancy is reduced compared with other animal models. Poly(ADP-ribose) polymerase (PARP) is… CONTINUE READING

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