Proteases in host cell invasion by the malaria parasite.

  title={Proteases in host cell invasion by the malaria parasite.},
  author={Michael J. Blackman},
  journal={Cellular microbiology},
  volume={6 10},
The life cycle of the malaria parasite contains three distinct invasive forms, or zoites. For at least two of these--the sporozoite and the blood-stage merozoite--invasion into their respective host cell requires the activity of parasite proteases. This review summarizes the evidence for this, discusses selected well-described proteolytic modifications linked to invasion, and describes recent progress towards identifying the proteases involved.