Proteases in gastrointestinal neoplastic diseases.

  title={Proteases in gastrointestinal neoplastic diseases.},
  author={L{\'a}szl{\'o} Hersz{\'e}nyi and Mario Plebani and Paolo Carraro and Massimo De Paoli and Giovanni Roveroni and Romilda Cardin and Francesca Foschia and Zsolt Tulassay and Remo Naccarato and Fabio Farinati},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  volume={291 2},
Cysteine and serine proteases are involved in cancer invasion and metastasis. In the past few years we investigated the tissue levels of these proteases in gastric cancer (GC), gastric precancerous changes (CAG), colorectal cancer (CRC) and the plasma and serum levels of proteases in several gastrointestinal tumours, using ELISA methods. Significantly higher antigen levels were found not only in GC tissue but also in CAG with respect to the levels found normal tissue; with respect to CAG… CONTINUE READING