Proteases as drug targets.

  title={Proteases as drug targets.},
  author={Andy J P Docherty and Tom Crabbe and James P. O'Connell and Colin R. Groom},
  journal={Biochemical Society symposium},
The effective management of AIDS with HIV protease inhibitors, or the use of angiotensin-converting enzyme inhibitors to treat hypertension, indicates that proteases do make good drug targets. On the other hand, matrix metalloproteinase (MMP) inhibitors from several companies have failed in both cancer and rheumatoid arthritis clinical trials. Mindful of… CONTINUE READING