Protease recognition sites in Bet v 1a are cryptic, explaining its slow processing relevant to its allergenicity

@inproceedings{Freier2015ProteaseRS,
  title={Protease recognition sites in Bet v 1a are cryptic, explaining its slow processing relevant to its allergenicity},
  author={Regina Freier and Elfriede Dall and Hans Brandstetter},
  booktitle={Scientific reports},
  year={2015}
}
Despite a high similarity with homologous protein families, only few proteins trigger an allergic immune response with characteristic TH2 polarization. This puzzling observation is illustrated by the major birch pollen allergen Bet v 1a and its hypoallergenic protein isoforms, e.g., Bet v 1d. Given the key role of proteolytic processing in antigen presentation and T cell polarization, we investigated the recognition of Bet v 1 isoforms by the relevant protease cathepsin S. We found that at… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Round-the-horn site-directed mutagenesis, < http://openwetware.org/wiki/%27Round-the-horn_site-directed_ mutagenesis> (2005) Date of access: 24/05/2015

  • S. Moore
  • 2015

Cellular and molecular immunology

  • A. K. Abbas, A. H. Lichtman, S. Pillai
  • 2012

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