Protease propeptide structures, mechanisms of activation, and functions

@article{Boon2020ProteasePS,
  title={Protease propeptide structures, mechanisms of activation, and functions},
  author={Lise Boon and Estefan{\'i}a Ugarte-Berzal and Jennifer Vandooren and Ghislain Opdenakker},
  journal={Critical Reviews in Biochemistry and Molecular Biology},
  year={2020},
  volume={55},
  pages={111 - 165}
}
Abstract Proteases are a diverse group of hydrolytic enzymes, ranging from single-domain catalytic molecules to sophisticated multi-functional macromolecules. Human proteases are divided into five mechanistic classes: aspartate, cysteine, metallo, serine and threonine proteases, based on the catalytic mechanism of hydrolysis. As a protective mechanism against uncontrolled proteolysis, proteases are often produced and secreted as inactive precursors, called zymogens, containing inhibitory N… 

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