Protease nexin. Properties and a modified purification procedure.

  title={Protease nexin. Properties and a modified purification procedure.},
  author={Richard W. Scott and B L Bergman and Anshuman Bajpai and Robert T. Hersh and Henry Rodriguez and Barry N. Jones and Carlos Barreda and Suzanne Watts and Joffre B. Baker},
  journal={The Journal of biological chemistry},
  volume={260 11},
The present paper describes chemical and functional properties of protease nexin, a serine protease inhibitor released from cultured human fibroblasts. It is shown that protease nexin is actually synthesized by fibroblasts and represents about 1% of their secreted protein. Analysis of the amino acid composition of purified protease nexin indicates that it is evolutionarily related to antithrombin III and heparin cofactor II. Protease nexin contains approximately 6% carbohydrate, with 2.3% amino… CONTINUE READING


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