Protease-nexin I as an androgen-dependent secretory product of the murine seminal vesicle.

  title={Protease-nexin I as an androgen-dependent secretory product of the murine seminal vesicle.},
  author={Jean Dominique Vassalli and Joachim Huarte and Domenico Bosco and A P Sappino and N Sappino and Andrea Velardi and Annelise Wohlwend and Henrik Ern\o and Denis Monard and Dominique Belin},
  journal={The EMBO journal},
  volume={12 5},
A search for inhibitors of urokinase-type plasminogen activator (uPA) in the male and female murine genital tracts revealed high levels of a uPA ligand in the seminal vesicle. This ligand is functionally, biochemically and immunologically indistinguishable from protease-nexin I (PN-I), a serpin ligand of thrombin and uPA previously detected only in mesenchymal cells and astrocytes. A survey of murine tissues indicates that PN-I mRNA is most abundant in seminal vesicles, where it represents 0.2… CONTINUE READING


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