Protease inhibitors suppress the formation of tight junctions in gastrointestinal cell lines.

@article{Bacher1992ProteaseIS,
  title={Protease inhibitors suppress the formation of tight junctions in gastrointestinal cell lines.},
  author={Adelbert Bacher and K Griebl and S Mackamul and R. Mitreiter and Harald M{\"u}ckter and Yehuda Ben-Shaul},
  journal={Experimental cell research},
  year={1992},
  volume={200 1},
  pages={97-104}
}
Tight junctions (TJ) of the fascia occludens type can be induced in the human colon adenocarcinoma cell lines HT29 and Caco-2 by treatment with 320 mM cesium sulfate. This process can be completely inhibited by the protease inhibitors leupeptin and antipain. The concentration for 50% inhibition was 32 microM leupeptin and 270 microM antipain, respectively. In the polarized colon carcinoma cell line Caco-2, the spontaneous formation of histotypical TJ and the development of transepithelial… CONTINUE READING
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