Protease inhibitors and rifabutin: isn't the jury still out?

Abstract

Use of rifabutin with protease inhibitors for human immu-nodeficiency virus-infected patients with tuberculosis. Sir—The attempt by Narita et al. [1] to delineate the pharmacokinetic interactions between HIV type 1 protease in-hibitors (PIs) and rifabutin administered intermittently addresses the practical question of juggling intermittent directly observed… (More)

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