Protease inhibitors and cardiovascular outcomes in patients with HIV-1

  title={Protease inhibitors and cardiovascular outcomes in patients with HIV-1},
  author={Scott Holmberg and Anne C. Moorman and John M. Williamson and Tony C Tong and the HIV Outpatient Study investigators},
  journal={The Lancet},
Protease inhibitors for treatment of HIV-1 have been linked with increased risk of hyperlipidaemia and hyperglycaemia. In a cohort of 5672 outpatients with HIV-1 seen at nine US HIV clinics between January, 1993, and January, 2002, the frequency of myocardial infarctions increased after the introduction of protease inhibitors in 1996 (test for trend, p=0.0125). We noted that 19 of 3247 patients taking, but only two of 2425 who did not take, protease inhibitors had a myocardial infarction (odds… CONTINUE READING
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