Protease inhibitor therapy for hepatitis C virus-infection

  title={Protease inhibitor therapy for hepatitis C virus-infection},
  author={Philipp de Leuw and Christoph Stephan},
  journal={Expert Opinion on Pharmacotherapy},
  pages={577 - 587}
ABSTRACT Introduction: The hepatitis C virus (HCV) has affected an estimated of 80 million individuals worldwide and is a strain on public health. Around 25–30% of patients in Europe and the US who are infected with HIV are coinfected with HCV. Prior to 2013, treatment modalities containing an NS3/4A protease inhibitor in combination with pegylated interferon and ribavirin improved sustained virological response (SVR) rates. However, rates of severe side effects were high. Nowadays, oral direct… 

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