Protease degradomics: A new challenge for proteomics

  title={Protease degradomics: A new challenge for proteomics},
  author={Carlos L{\'o}pez-Ot{\'i}n and Christopher M. Overall},
  journal={Nature Reviews Molecular Cell Biology},
Degradomics — the application of genomic and proteomic approaches to identify the protease and protease-substrate repertoires, or 'degradomes', on an organism-wide scale — promises to uncover new roles for proteases in vivo. This knowledge will facilitate the identification of new pharmaceutical targets to treat disease. Here, we review emerging degradomic techniques and concepts. 

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