Protease-defective, gp120-containing human immunodeficiency virus type 1 particles induce apoptosis more efficiently than does wild-type virus or recombinant gp120 protein in healthy donor-derived peripheral blood T cells.

@article{Kameoka1997ProteasedefectiveGH,
  title={Protease-defective, gp120-containing human immunodeficiency virus type 1 particles induce apoptosis more efficiently than does wild-type virus or recombinant gp120 protein in healthy donor-derived peripheral blood T cells.},
  author={Masanori Kameoka and Tetsuya Kimura and Ying Zheng and Shinichi Suzuki and Koh Fujinaga and Ronald B. Luftig and Kazuyoshi Ikuta},
  journal={Journal of clinical microbiology},
  year={1997},
  volume={35 1},
  pages={
          41-7
        }
}
Apoptosis and syncytium formation are two mechanisms by which human immunodeficiency virus type 1 (HIV-1) impairs uninfected CD4+ T-cell function and are mainly involved in the progression of the disease to AIDS. Previously, we showed that gp120-containing, protease-deficient HIV-1 (L-2) particles generated syncytia by particle-mediated fusion with uninfected cultured CD4+ T cells. Here, we present evidence that such L-2 particles can induce apoptosis in 40 to 50% of T cells which were enriched… CONTINUE READING

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