Protease concentration in amniotic fluid at term and early childhood respiratory symptoms.

@article{Turner2014ProteaseCI,
  title={Protease concentration in amniotic fluid at term and early childhood respiratory symptoms.},
  author={Steve W Turner and Jane Victoria Carter and Peter J. Danielian and Iain Chalmers and Laura A McConaghy and Nicandro Pacitti and Nuala Booth},
  journal={The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians},
  year={2014},
  volume={27 4},
  pages={416-20}
}
OBJECTIVE Asthma is a common chronic disease associated with altered proteolytic activity. The present study tested the hypothesis that altered protease concentration in amniotic fluid (AF), an index of airway fluid at birth, precedes early cough and wheeze. METHODS AF was collected and analysed for the following: matrix metalloproteinases (MMP) -2, -8 and -9, tissue inhibitor of metalloproteinases (TIMP) -1 and 2, plasminogen activator inhibitor (PAI)-1. Infant were followed up at ages 1, 2… CONTINUE READING
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