Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.

  title={Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.},
  author={Mark L. Kahn and Mayumi Nakanishi-Matsui and Michael J. Shapiro and Hiroshi Ishihara and Shaun R Coughlin},
  journal={The Journal of clinical investigation},
  volume={103 6},
Because of the role of thrombin and platelets in myocardial infarction and other pathological processes, identifying and blocking the receptors by which thrombin activates platelets has been an important goal. Three protease-activated receptors (PARs) for thrombin -- PAR1, PAR3, and PAR4 -- are now known. PAR1 functions in human platelets, and the recent observation that a PAR4-activating peptide activates human platelets suggests that PAR4 also acts in these cells. Whether PAR1 and PAR4… CONTINUE READING
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