Protease activated receptors 1 and 4 govern the responses of human platelets to thrombin.

Abstract

Studies carried out in the past 12 years have established that activation of protease-activated receptor (PAR)-1 and PAR-4 by thrombin essentially drives human platelet activation. Thrombin is the most potent physiologic agonist of platelets. PAR-1 and PAR-4 are found on human platelets and are half of the family of the four known 7-transmembrane receptors… (More)

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Cite this paper

@article{Ofosu2003ProteaseAR, title={Protease activated receptors 1 and 4 govern the responses of human platelets to thrombin.}, author={Frederick A. Ofosu}, journal={Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis}, year={2003}, volume={28 3}, pages={265-8} }