Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of β-arrestin.

Abstract

Vascular inflammation and thrombosis require the concerted actions of several different agonists, many of which act on G protein-coupled receptors (GPCRs). GPCR dimerization is a well-established phenomenon that can alter protomer function. In platelets and other cell types, protease-activated receptor-4 (PAR4) has been shown to dimerize with the purinergic… (More)
DOI: 10.1074/jbc.M117.782359

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Cite this paper

@article{Smith2017ProteaseactivatedRA, title={Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of β-arrestin.}, author={Thomas H Smith and Julia G Li and Michael Robert Dores and Joann Trejo}, journal={The Journal of biological chemistry}, year={2017}, volume={292 33}, pages={13867-13878} }