Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice.

@article{Amadesi2006ProteaseactivatedR2,
  title={Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice.},
  author={Silvia Amadesi and Graeme S Cottrell and Lorna A Divino and Kevin E. Chapman and Eileen F. Grady and Francisco Bautista and Rustum Karanjia and Carlos Barajas-L{\'o}pez and Stephen Vanner and Nathalie Vergnolle and Nigel W Bunnett},
  journal={The Journal of physiology},
  year={2006},
  volume={575 Pt 2},
  pages={555-71}
}
Proteases that are released during inflammation and injury cleave protease-activated receptor 2 (PAR2) on primary afferent neurons to cause neurogenic inflammation and hyperalgesia. PAR2-induced thermal hyperalgesia depends on sensitization of transient receptor potential vanilloid receptor 1 (TRPV1), which is gated by capsaicin, protons and noxious heat. However, the signalling mechanisms by which PAR2 sensitizes TRPV1 are not fully characterized. Using immunofluorescence and confocal… CONTINUE READING

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