Protease-activated receptor 2-mediated vasodilatation in humans in vivo: role of nitric oxide and prostanoids.


BACKGROUND Systemic hypotension as a consequence of vascular dysfunction is a well-recognized and important feature of critical illness. Although serine protease activation has been implicated as a cause of vascular dysfunction in systemic inflammation, the mechanism is unknown. Recently, a class of receptors with an entirely novel mechanism of action… (More)


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