Protease-activated receptor-2 induces myofibroblast differentiation and tissue factor up-regulation during bleomycin-induced lung injury: potential role in pulmonary fibrosis.

@article{Borensztajn2010ProteaseactivatedRI,
  title={Protease-activated receptor-2 induces myofibroblast differentiation and tissue factor up-regulation during bleomycin-induced lung injury: potential role in pulmonary fibrosis.},
  author={Keren S Borensztajn and Paul Bresser and Chris van der Loos and Ilze Bot and Bernt van den Blink and Michael A den Bakker and Joost B. Daalhuisen and Angelique P A Groot and Maikel P Peppelenbosch and Jan H. von der Th{\"u}sen and C. Arnold Spek},
  journal={The American journal of pathology},
  year={2010},
  volume={177 6},
  pages={2753-64}
}
Idiopathic pulmonary fibrosis constitutes the most devastating form of fibrotic lung disorders and remains refractory to current therapies. The coagulation cascade is frequently activated during pulmonary fibrosis, but this observation has so far resisted a mechanistic explanation. Recent data suggest that protease-activated receptor (PAR)-2, a receptor… CONTINUE READING