Protease-activated receptor-2 exerts contrasting model-specific effects on acute experimental pancreatitis.

  title={Protease-activated receptor-2 exerts contrasting model-specific effects on acute experimental pancreatitis.},
  author={Johanna M Laukkarinen and Eric R. Weiss and Gijs J. D. van Acker and Michael L. Steer and George Perides},
  journal={The Journal of biological chemistry},
  volume={283 30},
Protease-activated receptor-2 (PAR2) is a 7-transmembrane G-protein-coupled tethered ligand receptor that is expressed by pancreatic acinar and ductal cells. It can be physiologically activated by trypsin. Previously reported studies (Namkung, W., Han, W., Luo, X., Muallem, S., Cho, K. H., Kim, K. H., and Lee, M. G. (2004) Gastroenterology 126, 1844-1859; Sharma, A., Tao, X., Gopal, A., Ligon, B., Andrade-Gordon, P., Steer, M. L., and Perides, G. (2005) Am. J. Physiol. 288, G388-G395) have… CONTINUE READING
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