Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms.

  title={Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms.},
  author={Xiao Su and Eric Camerer and Justin R Hamilton and Shaun R Coughlin and Michael A. Matthay},
  journal={Journal of immunology},
  volume={175 4},
Protease-activated receptors (PARs) and tachykinin-immunoreactive fibers are located in the lung as sentries to respond to a variety of pathological stimuli. The effects of PAR activation on the lung have not been adequately studied. We report on the effects of instilling PAR-activating peptides (PAR-APs, including PAR1-, PAR2-, and PAR4-AP) into the lungs of ventilated or spontaneously breathing mice. PAR2-AP, but not PAR1-AP or PAR4-AP, caused a sharp increase in lung endothelial and… CONTINUE READING

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