Protease-activated receptor-2 activation: a major actor in intestinal inflammation

  title={Protease-activated receptor-2 activation: a major actor in intestinal inflammation},
  author={E. Hyun and P. Andrade-Gordon and M. Steinhoff and N. Vergnolle},
  pages={1222 - 1229}
  • E. Hyun, P. Andrade-Gordon, +1 author N. Vergnolle
  • Published 2008
  • Chemistry, Medicine
  • Gut
  • Background and aims: The role of protease-activated receptor-2 (PAR2) during intestinal inflammation is still unclear due to the fact that PAR2-activating peptide has both pro- and anti-inflammatory properties. The aim of this study was to investigate the effects of PAR2 deficiency (using PAR2-deficient mice, PAR2−/−) in models of colitis, in order to elucidate the role of endogenous PAR2 in the process of inflammation in the gut. Methods: Colonic inflammation in wild-type and PAR2−/− mice was… CONTINUE READING
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