Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.

@article{Poole2013ProteaseactivatedR2,
  title={Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.},
  author={Daniel P Poole and Silvia Amadesi and Nicholas A. Veldhuis and Fe C. Abogadie and TinaMarie Lieu and William G Darby and Wolfgang B Liedtke and Michael J. Lew and Peter Mcintyre and Nigel W Bunnett},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 8},
  pages={
          5790-802
        }
}
G protein-coupled receptors of nociceptive neurons can sensitize transient receptor potential (TRP) ion channels, which amplify neurogenic inflammation and pain. Protease-activated receptor 2 (PAR(2)), a receptor for inflammatory proteases, is a major mediator of neurogenic inflammation and pain. We investigated the signaling mechanisms by which PAR(2) regulates TRPV4 and determined the importance of tyrosine phosphorylation in this process. Human TRPV4 was expressed in HEK293 cells under… CONTINUE READING
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