Protease-activated receptor-2 (PAR-2) is a weak enhancer of mucin secretion by human bronchial epithelial cells in vitro.

@article{Lin2008ProteaseactivatedR,
  title={Protease-activated receptor-2 (PAR-2) is a weak enhancer of mucin secretion by human bronchial epithelial cells in vitro.},
  author={Ko-Wei Lin and Joungjoa Park and Anne L. Crews and Yuehua Li and Kenneth B. Adler},
  journal={The international journal of biochemistry & cell biology},
  year={2008},
  volume={40 6-7},
  pages={
          1379-88
        }
}
PAR-2, a member of a family of G-protein-coupled receptors, can be activated by serine proteases via proteolytic cleavage. PAR-2 expression is known to be upregulated in respiratory epithelium subsequent to inflammation in asthma and chronic obstructive pulmonary disease (COPD). Since these diseases also are characterized by excessive mucus production and secretion, we investigated whether PAR-2 could be linked to mucin hypersecretion by airway epithelium. Normal human bronchial epithelial… CONTINUE READING

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