Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1–dependent leukocyte recruitment in vivo

@article{Chen2008ProteaseactivatedR1,
  title={Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1–dependent leukocyte recruitment in vivo},
  author={Daxin Chen and Adam J Carpenter and Joel M Abrahams and Rachel C Chambers and R. Lechler and John H Mcvey and Anthony Dorling},
  journal={The Journal of Experimental Medicine},
  year={2008},
  volume={205},
  pages={1739 - 1746}
}
Thrombin, acting through a family of protease-activated receptors (PARs), is known to amplify inflammatory responses, but the in vivo importance of PARs in inflammation is not fully appreciated. In a mouse heart-to-rat transplant model, where it is possible to distinguish graft (mouse) from systemic (rat) chemokines, we show that donor PAR-1 is required to generate the local monocyte chemoattractant protein (MCP)-1 needed to recruit rat natural killer cells and macrophages into the hearts. We… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

Thrombin and vascular inflammation

Molecular and Cellular Biochemistry • 2011
View 7 Excerpts
Highly Influenced

Regulation of skeletal muscle regeneration by CCR2-activating chemokines is directly related to macrophage recruitment.

American journal of physiology. Regulatory, integrative and comparative physiology • 2010
View 5 Excerpts
Highly Influenced

Outside-in HLA class I signaling regulates ICAM-1 clustering and endothelial cell-monocyte interactions via mTOR in transplant antibody-mediated rejection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons • 2018
View 1 Excerpt

Thrombalexins: Cell-Localized Inhibition of Thrombin and Its Effects in a Model of High-Risk Renal Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons • 2017
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-4 of 4 references

The interface between coagulation and immunity

S. R. Holdsworth
Am . J . Transplant . • 2007

Absence of proteinaseactivated receptor1 signaling aff ords protection from bleomycininduced lung infl ammation and fi brosis

J. S. McLean, F. McGarry
Am . J . Pathol . • 2005

human vascular endothelium in vitro and in vivo

L. C. Casey
Mol. Cell. Biochem • 1995

Similar Papers

Loading similar papers…