Protease-activated Receptor 1 ( PAR 1 ) and PAR 4 Heterodimers Are Required for PAR 1-enhanced Cleavage of PAR 4 by-Thrombin *

@inproceedings{Arachiche2013ProteaseactivatedR1,
  title={Protease-activated Receptor 1 ( PAR 1 ) and PAR 4 Heterodimers Are Required for PAR 1-enhanced Cleavage of PAR 4 by-Thrombin *},
  author={Amal Arachiche and Michele M. Mumaw and Maria Isabel de la Fuente and Marvin T Nieman},
  year={2013}
}
Background: Protease-activated receptor 1 (PAR1) and PAR4 mediate thrombin signaling in platelets. Results:Mutations in transmembrane helix 4 (TM4) of PAR1 or PAR4 disrupts -thrombin-induced heterodimerization and PAR1-assisted PAR4 cleavage. Conclusion: PAR1-PAR4 heterodimers are required for efficient PAR4 cleavage. Significance: The dimerization of PAR1 and PAR4 may impact the effectiveness of PAR1 antagonists. 
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