Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction

@article{Chmela2017ProteaseII,
  title={Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction},
  author={J. Chmelař and Jan Kot{\'a}l and H. Langhansov{\'a} and Michail Kotsyfakis},
  journal={Frontiers in Cellular and Infection Microbiology},
  year={2017},
  volume={7}
}
  • J. Chmelař, Jan Kotál, +1 author Michail Kotsyfakis
  • Published 2017
  • Biology, Medicine
  • Frontiers in Cellular and Infection Microbiology
  • The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host. Three major groups of protease inhibitors are secreted into saliva: Kunitz inhibitors, serpins, and cystatins. Kunitz inhibitors are anti-hemostatic agents and tens of proteins with one or more Kunitz domains are known to block host coagulation and/or platelet… CONTINUE READING
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