Protease Inhibitors for the Treatment of HIV/AIDS: Recent Advances and Future Challenges.

  title={Protease Inhibitors for the Treatment of HIV/AIDS: Recent Advances and Future Challenges.},
  author={Chandrashekhar Voshavar},
  journal={Current topics in medicinal chemistry},
Acquired Immunodeficiency Syndrome (AIDS) is a chronic disease characterized by multiple life-threatening illnesses caused by a retro-virus, Human Immunodeficiency Virus (HIV). HIV infection slowly destroys the immune system and increasing the risk of various other infections and diseases. Although there is no immediate cure for HIV infection/AIDS, several drugs targeting various cruxes of HIV infection are used to slow down the progress of the disease and to boost the immune system. One of the… 

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The major progresses and drawbacks of HIV/AIDS chemotherapy (HAART) to HIV/ AIDS patients have been discussed and future trends (updating pathogenesis study, next generations of drug developments, new drug target discovery, different scientific disciplinary and so on) are highlighted.

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In this review, studies conducted in the last two decades on the mechanism of HIV PR and the impact of their conclusions on the drug discovery processes are summarized.

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The difficult treatment regimens, the presence of class-specific drug toxicities, and the emergence of drug-resistant virus isolates highlight the fact that improvements in therapeutic regimens and the identification of new and novel viral and cellular targets for therapy are still necessary.

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    Cold Spring Harbor perspectives in medicine
  • 2012
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  • P. Piliero
  • Biology, Chemistry
    Expert opinion on investigational drugs
  • 2002
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Antiretroviral drugs

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In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

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