Protease Inhibitors for the Treatment of HIV/AIDS: Recent Advances and Future Challenges.

@article{Voshavar2019ProteaseIF,
  title={Protease Inhibitors for the Treatment of HIV/AIDS: Recent Advances and Future Challenges.},
  author={Chandrashekhar Voshavar},
  journal={Current topics in medicinal chemistry},
  year={2019}
}
Acquired Immunodeficiency Syndrome (AIDS) is a chronic disease characterized by multiple life-threatening illnesses caused by a retro-virus, Human Immunodeficiency Virus (HIV). HIV infection slowly destroys the immune system and increasing the risk of various other infections and diseases. Although there is no immediate cure for HIV infection/AIDS, several drugs targeting various cruxes of HIV infection are used to slow down the progress of the disease and to boost the immune system. One of the… 
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38 Citations

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Pharmacokinetic Parameters of HIV‐1 Protease Inhibitors

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The research explains the evolutionary characteristics of coronaviruses under antiviral drugs, which is helpful for a more comprehensive understanding of the molecular basis of virus resistance and provides important basic data for the effective prevention and control of CoVs.

Development of A Fission Yeast Cell-based Platform for High Throughput Screening of HIV-1 Protease Inhibitors.

A fission yeast cell-based HTS platform that is suitable for high throughput screening (HTS) of small molecules against HIV-1 protease (PR) and to exclude all hidden nmt1 inhibitors is successfully developed.

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The role players, such as HPV oncoproteins involved cervical cancer development and how they are targeted in HIV protease inhibitors-induced p53 restoration in cervical cancer are evaluated.

Reviewing HIV-1 Gag Mutations in Protease Inhibitors Resistance: Insights for Possible Novel Gag Inhibitor Designs

The structural role of both novel and previously reported Gag mutations in PI resistance, and how new Gag inhibitors can be designed are discussed.

Machine intelligence-guided selection of optimized inhibitor for human immunodeficiency virus (HIV) from natural products.

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