Protease Activated Receptor-2 Contributes to Heart Failure

  title={Protease Activated Receptor-2 Contributes to Heart Failure},
  author={Silvio Antoniak and Erica M Sparkenbaugh and Michael Tencati and M. Diaz de Rojas and Nigel Mackman and Rafal Pawlinski},
  booktitle={PloS one},
Heart failure is a major clinical problem worldwide. Previous studies have demonstrated an important role for G protein-coupled receptors, including protease-activated receptors (PARs), in the pathology of heart hypertrophy and failure. Activation of PAR-2 on cardiomyocytes has been shown to induce hypertrophic growth in vitro. PAR-2 also contributes to myocardial infarction and heart remodeling after ischemia/reperfusion injury. In this study, we found that PAR-2 induced hypertrophic growth of… CONTINUE READING
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